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Bears vs. Bills: Picks, predictions, best bets from expert on 32-23 run, 2021 NFL preseason odds, lines

Quarterback Mitchell Trubisky will make his return to Chicago on Saturday when his new team, the Buffalo Bills, takes on his former team, the Chicago Bears, in a Week 2 preseason game. Trubisky was famously selected by Chicago at No. 2 overall in the 2017 NFL Draft, ahead of Patrick Mahomes and Deshaun Watson. Trubisky went 29-21 over four seasons and 0-2 in the playoffs despite the Bears having one of the league’s best defenses. In March, he signed a one-year contract with the Bills to back up Josh Allen.

Kickoff for Bills vs. Bears is set for 1 p.m. ET. Chicago is a 4.5-point favorite in the latest Bears vs. Bills odds from Caesars Sportsbook, while the over-under for total points scored is 38. Before you make any Bills vs. Bears picks of your own, you need to check out what NFL expert R.J. White has to say.

CBS Sports’ Fantasy and gambling editor, White ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. That’s no surprise, as White has cashed huge twice in the world’s most prestigious football handicapping competition, the Las Vegas SuperContest. Plus, White is 32-23-1 on his last 56 NFL expert picks against the spread involving the Bears, and anyone who has followed him is way up.

Now, he has locked in on Bears vs. Bills and recently released his expert NFL picks for this preseason matchup. You can head to SportsLine now to see his picks. Here are the NFL odds, lines and betting trends for Bills vs. Bears:

  • Bears vs. Bills spread: Chicago -4.5
  • Bears vs. Bills Over/Under: 38 points 
  • Bears vs. Bills money line: Chicago -200, Buffalo +175 
  • CHI: Khalil Mack has 66.5 sacks over the last six seasons, third in the NFL 
  • BUF: Stefon Diggs led the NFL in receptions (127) and receiving yards (1,535) last season

Featured Game | Chicago Bears vs. Buffalo Bills

Why the Bears can cover

Justin Fields gives Chicago’s offense a passing and a running threat. Last week in his preseason debut against Miami, the rookie quarterback from Ohio State hit 14-of-20 passes for 142 yards and two touchdowns. He also scored on an eight-yard touchdown run and rushed for 33 yards on the day.

In addition, the Bears will face a Bills team that will not play several key starters. On Thursday, Buffalo coach Sean McDermott said that quarterback Josh Allen and receiver Stefon Diggs are two of the players who will not see action. Trubisky will start in Allen’s place.

Why the Bills can cover

Buffalo has improved depth on defense this season. The team used its first two picks in the draft to select defensive ends Greg Rousseau and Boogie Basham and also added former Panthers end Efe Obada (5.5 sacks last season) as a free agent. In last week’s preseason opener, Buffalo limited Detroit to 2.7 yards per play in the first half before both teams started emptying their benches.

Rousseau has been particularly impressive. In his first NFL series, he got to Lions quarterback Jared Goff for a sack, continuing the strong play that has been reported from summer camp. He helped the Bills defense rack up four sacks of Detroit quarterbacks.

How to make Bears vs. Bills picks

White has analyzed this matchup from every angle and while we can tell you he’s leaning over on the point total, he has discovered a crucial x-factor that makes one side of the spread a must-back. He’s sharing this pick and his NFL expert analysis only at SportsLine.

Who wins Bills vs. Bears? And what critical x-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Bears vs. Bills spread you should jump on, all from the top NFL expert who’s 32-23 on Bears picks, and find out.

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